Detailed Introduction

The Whole-body Plethysmograph (WBP) developed by Tow-Int Tech is capable of measuring respiratory parameters of laboratory animals in conscious state and under unrestrained condition, such as respiratory rate, tide volume, Airway Hyperresponsiveness (AHR) test, etc.

Product Description

The Whole-body Plethysmograph (WBP) developed by Tow-Int Tech is capable of measuring respiratory parameters of laboratory animals in conscious state and under unrestrained condition, such as respiratory rate, tide volume, Airway Hyperresponsiveness (AHR) test, etc. WBP avoids the trauma of aerosols tube incision and the effects of anesthesia, making the whole experimental process simpler. It is used to study the reaction of animal models to drugs, the pharmacology and toxicology of respiratory drugs, especially suitable for a large badge animal models for rapid initial screening test, long-term follow-up research and repetitive screening.

Product Features

lNo operation is required and the instrument is easy to use

lMulti-channel simultaneous monitoring

lIt can be used in the study of respiration of animals in the natural state and long-term follow-up experiment, which is suitable for initial screening of drugs

lDrug aerosol atomization module is available

lAutomatic calibration function

lThere are drinking water and food ports for long-term continuous monitoring

lOptional functions are available, for example the measurements of ECG, blood pressure, body temperature, heart rate and other vital signs, which can be combined with implantable telemetry equipment

lEquipped with analysis software, data can be saved in Excel or TXT format

Test Parameters

• Ti: Inspiratory Time (s)

• Te: Expiratory Time (s)

• PIF: Peak Inspiratory Flow (ml/s)

• PEF: Peak Expiratory Flow (ml/s)

• Volbal:Difference between Inspiratory/Expiratory Volume

• F:Flowrate (breaths per minute)

• Vt:Tidal Volume（ml）

• Mv:Minute Ventilation（ml）

• AV:Accumulated Volume（ml）

• EF50: Mid-tidal Expiratory Flow

• EIP:End-inspiratory Pause (Invasive Method)

• EEP:End-expiatory Pause (Invasive Method)

• TR: Relax Time

• PenH:Enhanced Pause

• Rpef:Ratio of Time to Peak Expiratory Flow

Applications

1. Researches on various respiratory diseases, such as asthma, pulmonary fibrosis, lung injury, ARDS, lung cancer, etc.

2. Safety pharmacology: the effect of drugs on the respiratory system

3. Sleep apnea: monitor animal hypopnea, obstructive apnea, etc.

4. Environmental Toxicology: The impact of environmental pollutants on animal respiration

5. Inhalation Toxicology: Toxic effects of toxic substances on the respiratory system

6. High altitude medicine: The influence of high altitude environment on the respiratory system

7. Other occasions where respiratory parameters need to be evaluated

Configuration

Ender-User List

[1]Sun Lingna,Fan Mingrui,Huang Dong,Li Bingqin,Xu Ruoting,Gao Feng,Chen Yanzuo. Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis[J]. Biomaterials,2021(prepublish):

[2]李宁,李红鹏,张本炎,张柳,沈继敏,李庆云.高脂膳食对小鼠呼吸功能和膈肌纤维的影响及其线粒体机制[J].中华医学杂志,2021,101(36):2893-2899.

[3]Xiong Jiaying,Zhuang Tao,Ma Yurong,Xu Junyi,Ye Jiaqi,Ma Ru,Zhang Shuang,Liu Xin,Liu Bi-Feng,Hao Chao,Zhang Guisen,Chen Yin. Optimization of bifunctional piperidinamide derivatives as σ1R Antagonists/MOR agonists for treating neuropathic pain[J]. European Journal of Medicinal Chemistry,2021,226:

*Our company can provide customized services according to customers' special applications, requirements, as well as experimental services. Please kindly contact us for more information.

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  Whole-body Plethysmography System for Rats

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  Whole-body Plethysmography System for Mice